Health information technology (HIT) promises to enhance patient safety and quality of care and standardize care across populations through use of electronic patient records, support for physician decision making, computerized prescription entry, health information exchanges, and more. Skeptics, however, warn that these same tools could dehumanize the patient-physician relationship, compromise patient information, and encourage physicians to perform procedures that pop up in clinical decision checklists but are not indicated for the patient in the office. This month’s contributors negotiate these competing ethical claims.